PMC

A, Arthroscopic image showing synovitis of the knee; B, cyclops lesion at the intercondylar notch; C, well surrounded cyclops with synovitis; D, granulation tissue once cyclops is opened; E, frontal view of cyclops lesion; F, intact ACL after cyclops excision; G, intact medial meniscus with chondral frame.

Sites of occurrence of cyclops lesion and its variants: classic cyclops lesion at the tibial attachment of the anterior cruciate ligament (ACL) graft (A), inverted cyclops lesion at the femoral side (B), and atypical cyclops lesion in the midsubstance of the ACL graft (C).

A–D, MRI examination showing cyclops lesion. A, MRI coronal T2 weighted image showing cyclops lesion size of 18.47 mm; B, medial extension of cyclops lesion; C, MRI showed intact ACL with MCL repair seen; D, axial view showing position of cyclops lesion at the intercondylar notch.

Expression of selected clock-controlled drug targets in noncancerous liver as determined by CYCLOPS. Expression data from tissue obtained at biopsy was processed using CYCLOPS to reconstruct the circadian transcriptome in noncancerous (NC) human liver samples. Expression of selected drug targets is plotted as a function of CYCLOPS phase.